Relation between Cancer and Germ Cells
Background: Age of contraceptives, abortions,[20th, 21st centuries] initiated as observed by family welfare programs, increased global cancer, tumor, neoplasm and mortality incidence.
Objectives: Tumor altruistic association of contraception [if any] with growing cancer has been tried.
Methods: in 2012, retrospective study of cancer prevalence, tumor in 350 patients 20-35 years of age, 35-50 years of age, >50 years of age, from data collected by convenient stratified random sampling from different geographical locations between 2002-2012 and its association with presence, absence of contraception, abortion was performed; simultaneously, serum oestrogen levels were obtained from different geographical locations between 2002-2012 and its association with presence, absence of contraception, abortion; 212 patients treated for various forms of neoplasm, namely breast cancer, prostate cancer, cervix cancer and benign prostatic hyperplasia, were randomly allocated to the above 3 age groups from 1983-2012 clinical practice, and the data were analyzed for association with contraceptive status and potential significance.
Results: There was a 6-fold rise in the incidence of cancer among contraceptive users over >50 years with a p-value of <0.0005. Contraception was associated with a 4 to 7 fold increase in tumor prevalence with a p value of <0.0005 between >35 and >50 years. In 61 percent of contraceptive users with a p value of <0.0005, endogenous estrogen decreased to ~5-8 pg; endogenous estrogen values of up to ~0.4 pg were seen after hysterectomy. Due to reduced production of endogenous estrogen, diet deprived of cholesterol: androgen was also correlated with a 50 percent rise in tumor, cancer in youth without contraceptives. In well-differentiated breast cancers, associated with decreased levels of endogenous estrogen among contraceptive users, estrogen receptors were positive, indicating that estrogen receptor positivity may be a compensatory phenomenon; estrogen receptor positivity was not shown in anaplastic tumors. There was a 10-20 fold increase in breast cancer between 20->50 years, in contraceptive patients with a p-value of <0.0005; a 20-30 fold increase in prostate cancer between 35->50 years, in contraceptive patients with a p-value of <0.0005; in contraceptive patients with a p-value of <0.0005; in cervical patients with a 20-40 fold increase between 20-70 years; in contraceptive patients with a p-value of <0.0005.
Conclusion: Contraception of any sort results in shattered germ cell breakdown to centric fragments, ring chromosomes, chromatid breaks, auto immunity generation, substantial decrease in endogenous, reproductive hormones, without which genomic repertoire: embryo-like healing mechanism defaults, leading to a 275% rise in disease incidence, including cancers. Definition is acquired contraception preventing traversal of normal path by germ cells with consequent shattered destruction of germ cells, resulting in decreased endogenous estrogen: androgen surveillance, resulting in agonizing cellular genomic repertoire defects, unregulated multiplication followed by no cell cycle differentiation, metabolism, resulting in high cancer incidence, including. Increased estrogen receptors: androgen receptors in breast and well-differentiated prostate cancers are likely to be a compensatory spike, secondary to sudden artificially obtained contraception, resulting in a substantial reduction in contraceptive consumers of endogenous germ cell hormones. Reversal of contraception with chemotherapy, radiation therapy, surgery achieves preventing cancer development, decreases incidence, prevalence of neoplasm, as a phenomenon of cause and effect and not castration or anti-estrogen: antiandrogens that perpetuate, encourage neoplastic diseases by decreasing endogenous estrogen: androgen.
Author (s) Details
Elizabeth Jeya Vardhini Samuel
Department of General Medicine, Karpagam Faculty of Medical Sciences and Research, Coimbatore-32, Tamil Nadu, India.
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