Results of a Comparative Study on Fast Superposition, Superposition Algorithm in Intensity Modulated Radiotherapy Techniques for Prostate Cancer

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Results of a Comparative Study on Fast Superposition, Superposition Algorithm in Intensity Modulated Radiotherapy Techniques for Prostate Cancer

September 24, 2020 Medicine and Medical Science 0

This study aims to compare the dosimetric coverage of the Planning Target Volume (PTV) and the
dose to main organs at risk (OARs) between two dif-ferent algorithms fast superposition (FSUP),
superposition (SUP) using in-tensity-modulated radiotherapy (IMRT) techniques for prostate cancer.
Ten patients with prostate cancer were selected for this study. For each patient, IMRT plans were
created with 6 MV photon beam quality using CMS XiO treatment planning system. The delivery of
IMRT was carried out using the step and shoot techniques. The dose coverage for each patient was
designated to an ICRU report 62 reference point in the PTV, medium coverage of the planned target
volume to be 95% of the prescribed dose while the maximum dose in the target volume to be not
greater than 107% of the prescribed dose. A hypofractionated prescription dose of 70 Gy/28# at 2.5
Gy per fraction was used. For target, this evalua-tion was made with comparing the conformity index
(CI) and homogeneity index (HI). The results of the present study showed the OARs got less dose
from the SUP algorithm compared to FSUP algorithms. Statistically not significant difference was
observed in V107% of PTV, MU/CC, conformity Index (p = 0.057, p = 0.215, p = 0.370) and 95% PTV
Volume received prescription dose from both Plans. For prostate cancer, the superposition algorithm
showed better results in the IMRT plan compared to the fast superposition algorithm.

Author (s) Details

Dr. Mukesh Zope
Department of Medical Physics, State Cancer Institute, Indira Gandhi Institute of Medical Sciences, Patna, India.

Dr. Deepali Patil
Department of Medical Physics, State Cancer Institute, Indira Gandhi Institute of Department of Radiation Oncology, Paras HMRI Hospital, Patna, India.

Angel Kuriakose
Department of Radiotherapy, Mahavir Cancer Sansthan, Patna, India.

P. A. Aslam
Department of Radiotherapy, Mahavir Cancer Sansthan, Patna, India and Speciality of Medical Physics, Super Speciality of Cancer Institute and Hospital, Lucknow, India.

Basil George
Department of Radiotherapy, Regional Cancer Care Center and Cancer Hospital, Siddhpur, India.

Abhijit Mandal
Department of Radiotheraphy & Radiation Medicine, Institute of Medical Sciences, Varansi, India.

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