Role of Biochemical Parameter in Synthetic Biomolecular Network of Escherichia coli
With the toggle switch paradigm, the role of biochemical parameters (such as the rate constant of repressor expression) in determining the type of stability for altering gene regulation in Escherichia coli is well established. The resilience of the system improves with higher order cooperativity of promoter repression, which helps to achieve bistability in the event of weaker promoters. The histogram depicts the abrupt transition from a low to a high level. Two methodologies have been used to investigate the release of protein concentration with time. The effect of noise is investigated, and it is discovered that noise varies with system size. The level of noise is also measured.
Dr. Enakshi Guru
Sarojini Naidu College for Women. Kolkata. India.
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