Scintimetric Characterization of Left Ventricular Diastolic Dysfunction by Phase Image Analysis in Gated Thallium SPECT Scan
The aim of this study is to use gated thallium SPECT scans to identify and quantify the existence of diastolic dysfunction using the Scintimetric characterization theory. In the treatment of heart failure patients, the evaluation and differentiation of Left Ventricular Diastolic Dysfunction is crucial. E and A wave variations in m-mode echocardiographic changes at the mitral orifice are currently used to infer diastolic dysfunction. Peak Flow Rate and Time to Peak Flow Rate are calculated and evaluated for the occurrence and degree of diastolic dysfunction in gated myocardial perfusion imaging from the time volume curve. The underlying diastolic dysfunction causes all of these parameters to change, resulting in changes in the left ventricular muscle mass. For the first time, using visual Phase image analysis in Gated Thallium SPECT Scan, this study aims to illustrate the diagnosis of Left Ventricular Diastolic Dysfunction. Diastolic dysfunction is thought to be indicated by inhomogeneous, abnormal, and inadequate tracer accumulation in diastolic phase images compared to normal and homogeneous tracer distribution in systolic phase images. It also thrives on quantifying the changes seen by dividing the Systolic Counts by the diastolic counts obtained from the raw phase images to get the S/D ratio. It’s linked to the stages of Diastolic Dysfunction on echocardiography.
Materials and Methods: The participants in this sample are 75 men between the ages of 28 and 63, with a mean age of 47.9 +/- 7.8 years and 25 women between the ages of 32 and 55, with a mean age of 49 +/- 6.8 years. 2 mCi of Thallum-201 was administered intravenously after the patients were exercised on a bicycle ergometer using the Bruce Protocol. Siemens Dual Head E-Cam Gamma Camera was used to gain gated SPECT MPI. The GATED SPECT PERFUSION ANALYSIS Protocol was used for the analysis. The S/D ratio was determined using the ICON software’s area ratio count protocol.
The discrepancy between the diastolic and systolic images was observed in 98/100 (98 percent) of the cases- Image1,2. In 87/100 cases, echocardiographic evidence of diastolic dysfunction was detected, which was graded as Grade II or Grade III using E/A ratio analysis (87 percent ). Diabetes was found in 16/100 (16%) cases, and hypertension was found in 63/100 cases (63 percent ). In Grade IILVDD, the S/D ratio was 1.27 +/- 0.32, and in Grade III LVDD, it was 1.68 +/- 0.03.
Finally, for the first time, the value of direct visual individual step image analysis in detecting Left Ventricular Diastolic Dysfunction is illustrated. The Scintimetric Characterization of the same has been shown to be different between stage II and stage III LVDD using the S/D ratio.
Author (s) Details
Department of Nuclear Medicine & Molecular Imaging, Sri Aurobindo Institute of Medical Sciences, Sri Aurobindo University, Indore, Madhyapradesh, India and Department of Physics, Sri Sathya Sai Institute of Higher Learning, Vidhyagiri, Prasanthinilayam, Anantapur Dist. A.P 515134, India.
Department of Physics, Sri Sathya Sai Institute of Higher Learning, Vidhyagiri, Prasanthinilayam, Anantapur Dist. A.P 515134, India.
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