Serological Diagnosis of Dengue Fever and Its Correlation with Platelet Counts In a Tertiary Hospital, Nellore, Andhra Pradesh, South India

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Serological Diagnosis of Dengue Fever and Its Correlation with Platelet Counts In a Tertiary Hospital, Nellore, Andhra Pradesh, South India

July 9, 2021 Medicine and Medical 0

Dengue fever is an Arboviral infection spread by mosquitos that primarily affects tropical and subtropical countries worldwide. Due to a lack of immune prophylaxis and specific antiviral therapy, outbreaks occur almost every year. To avoid morbidity and mortality, a prompt diagnosis is required. Classical Dengue fever symptoms include a high fever, severe headache, chills, and generalized muscle and joint pain. The purpose of this study was to determine the dengue virus seroprevalence in a tertiary care hospital in Nellore. Serological tests were carried out on blood samples submitted to the microbiology laboratory. Between June and October of 2015, suspected dengue infections were sent to a lab. A solid phase immunochromatographic technique was used to detect NS1 antigen, IgG, and IgM antibodies in a Dengue Day 1 Test kit (J. Mitra & Co. Pvt Ltd). NS1 antigen positivity was found in 88.69% of the samples, 3.41 % for IgM, and 2.77 % for IgG. Thrombocytopenia was discovered in 71.42 percent of patients, with the highest rate found in those who were only positive for the NS1 antigen (301 cases). Because it combines antigen and antibody assays on a single serum sample and is simple and quick to perform, immunochromatography is the preferred test for making an accurate diagnosis.

Author (S) Details

M. Shabnum
Department of Microbiology, Narayana Medical College, Nellore – 524002, Andhra Pradesh, India.

P. Sreenivasulu Reddy
Department of Microbiology, Narayana Medical College, Nellore – 524002, Andhra Pradesh, India.

P. Vasundhara Devi
Department of Microbiology, Narayana Medical College, Nellore – 524002, Andhra Pradesh, India.

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