Studies on Antiphospholipid Syndrome

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Studies on Antiphospholipid Syndrome

August 23, 2021 Medicine and Medical 0

Antiphospholidid syndrome (APS) is a rare and poorly understood clinical disease that can have serious implications. The presence of antiphospholipid antibodies is what distinguishes it (aPL). These autoantibodies are directed towards plasma proteins having a high affinity for anionic phospholipids, rather than anionic phospholipids themselves. Arterial and venous thrombosis, as well as pregnant morbidity, are the most common symptoms. Catastrophic APS and immune thrombocytopenia are two further symptoms. Antibodies to lupus anticoagulant (LA), anticardiolipin (aCL), and anti-2-glycoprotein I (a-2GPI) are among the laboratory tests used to look for aPL. Individuals who have positive results for all three laboratory tests (triple positivity) are at the highest risk for a first thrombotic event and recurrence. Thrombotic recurrences are prevented by long-term anticoagulant therapy with warfarin.

Author (S) Details

Cacciola Rossella
University of Catania, Department of Clinical and Experimental Medicine, Haemostasis Unit, Ferrarotto Hospital, Via S. Citelli 6, 95124 Catania, Italy.

Gentilini Cacciola Elio
Haemostasis Unit, University of Catania, Italy.

Cacciola Emma
Haemostasis Unit, University of Catania, Italy.

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