Studies on UV Spectrophotometric Analysis of Drugs Terbinafine Hydrochloride and Clarithromycin

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Studies on UV Spectrophotometric Analysis of Drugs Terbinafine Hydrochloride and Clarithromycin

October 15, 2020 Chemistry 0

To ensure the availability of safe and efficient drug formulations to customers, quality assurance for the management of pharmaceutical chemicals and formulations is important. For maintaining and ensuring quality, quantitative estimation of the chemical entity of a drug is vital. In the quantitative estimation of the drug in bulk samples and formulations, several distinct problems are faced. The intrusion caused by a variety of sources, such as the deterioration of drug products when stored for a long period of time, the involvement of other drugs in the combination products and the different additives used in the formulations, must be taken into account during the production of the drug assay in the formulations. Uvvisible spectrophotometry combines the advantages of low cost , easy maintenance and simplicity with the advantages of low cost , simple maintenance and simplicity among the different techniques for developing assay methods. The probability, with good accuracy , precision and reliability, of achieving high sensitivity and selectivity. The selectivity and sensitivity of the uv-visible spectrophotometric system depends only on the existence of the chemical reactions involved in the formation of the colour and not on the equipment’s complexity. The expenditure incurred on the determination of the assay in visible spectrophotometric methods depends on the selection of the reagents for the colour production (low cost, readily available). I hereby enclose my research work on estimating terbinafine hydrochloride and clarithromycin with the aid of the UV spectrophotometric method as mentioned below with the above facts. For the assay of two drugs, namely terbinafine hydrochloride and clarithromycin in pure form and formulations, one simple and sensitive technique (UV spectophotometric method) is used. The development of the ion-association complex between TRB or CAM and picric acid is part of this technique. In order to determine the optimum conditions required for the rapid and quantitative formulation of the coloured product with maximum stability and sensitivity, the experiments were carried out by measuring the absorption at ╬╗max 350 nm of a series of solutions, varying one and fixing the other parameters in each case, such as the type, volume and concentration of acid, the organic solvent used for extraction, the ratio of acids, the ratio and the concentration of organic solvent used for extraction, They optimised the vector parameters. The findings were confirmed statistically. The study of regression using the For slope (b), standard deviation (Sb), intercept (a), standard deviation on intercept (Sa), standard estimation error ( Se) and coefficient of correlation ( r) obtained from different concentrations, the minimum square method was used. This section summarises the data obtained for the determination of each drug with different reagents. Via interference experiments with other active and inactive ingredients typically present in pharmaceutical preparations, the selectivity (or specificity) of each proposed method was determined.

Author (s) Details

R. Mrutyunjaya Rao
SRKR Engineering College, Chinna Ammiram, Bhimavaram, India.

C. S. P. Sastry
Foods and Drugs Laboratories, Department of Organic Chemistry Foods, Drugs and Water, Andhra University, Visakhapatnam-530003, India.

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