The research was conducted to determine the anticarcinogenic properties of “rumput mutiara” (Hedyotis corymbosa (L.) Lam) and “pohpohan” (Pilea trinervia (Roxb.) Wight), by the microculture tetrazolium salt (MTT) assay on the human breast carcinoma dependent-hormone (MCF-7) cell lines. The preliminary results showed that the “rumput mutiara” extract displayed the cytotoxic effects against MCF-7 with IC50-value of 22,67 µg/ml. However, the “pohpohan” extract did not show the IC50value against MCF-7 cell lines. The antioxidative activities of the extracts which could contribute to their cytotoxic properties were also studied. The “rumput mutiara” extract was found to have higher antioxidant activity compared with “pohpohan” extract. The strong cytotoxic properties of the “rumput mutiara” extract could be due to its high antioxidant activity. The combination effect of “rumput mutiara” and soursop were also studied.
Faculty of Medicine and Health Sciences, Universitas Abdurrab, Jl. Riau Ujung Pekanbaru Riau Indonesia.
Faculty of Medicine, Yarsi University, Cempaka Putih 10510, Jakarta, Indonesia.
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