Study on Association of Serum Uric Acid, Homocystine and Ferritin among Amyotrophic Lateral Sclerosis Patients in Bangladesh

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Study on Association of Serum Uric Acid, Homocystine and Ferritin among Amyotrophic Lateral Sclerosis Patients in Bangladesh

August 23, 2021 Medicine and Medical 0

The disease Amyotrophic lateral sclerosis (ALS) is characterised by the loss of neurons that control voluntary muscles. It’s also known as Lou Gehrig’s disease or motor neuron disease (MND). It’s possible that serum uric acid, homocystine, and ferritin are linked to amyotrophic lateral sclerosis.

However, we lack sufficient information on these subjects. The primary goal of this study was to look into the link between serum uric acid, homocystine, and ferritin and amyotrophic lateral sclerosis.

Materials and Methods: A case-control study was conducted at the department of neurology at Bangabandhu Sheikh Mujib Medical University in Dhaka, Bangladesh, from January 2010 to December 2011. Following the completion of the study, the 76 participants were divided into two equal groups, each having 38 participants. In group I (the case group), there were 38 ALS patients and 38 healthy persons (control group). Pre-designed questioners were used to collect data, which was subsequently processed and analysed using SPSS version 11.5.

Results: In this study, approximately 11% of patients in the case group and 5.3 percent of participants in the control group (a total of 15.8%) were merely former smokers. The mean (SD) uric acid level in the case group was 4.271.41 mg/dL, while it was 4.271.41 mg/dL in the control group, indicating a strong association between the two groups (p value > 0.05). We discovered a significant link between uric acid and gender of the case group when the p value was less than 0.05. Serum uric acid levels were found to be lower in females. In this investigation, blood uric acid levels were found to be inversely associated to disease duration and positively connected to the ALS functional rating scale.

Conclusion: Amyotrophic lateral sclerosis patients had lower serum UA levels than healthy people, and female ALS patients had lower levels than male ALS patients. In the case group, uric acid levels were favourably correlated with the ALSFRS-R (severity) and negatively correlated with disease duration. In the early stages of ALS, UA levels could be used as a biomarker for disease progression.

Author (s) Details

Md. Raknuzzaman
National Institute of Neurosciences & Hospital, Dhaka, Bangladesh.

Tasnim Jannaty
Department of Biochemistry & Molecular Biology, Dhaka University, Dhaka, Bangladesh.

Md. Anis Ahmed
Department of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

Abu Shams
Department of Neurology, Anwer Khan Modern Medical College, Dhaka, Bangladesh.

Md. Hasan Ali Masum
Department of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

Md. Masud Rana
Department of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

View Book :- https://stm.bookpi.org/NFMMR-V1/article/view/2787

 

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