Study on Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug

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Study on Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug

April 23, 2021 Science and Technology 0

By coupling with several arylboronic acids and methylation using two different methods, a sequence of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields. The anticancer activity of the indazole derivatives (3a-3j) and their N-methyl derivatives (5a-5j) is tested in vitro against two cancer cell lines, HCT-116 and MDA-MB-231. According to the findings, the indazole derivatives examined have mild to moderate anticancer activity against the cell lines studied. We believe that slight structural modifications to these active derivatives may result in more promising anticancer drugs, and that more experimental research, particularly in the area of anticancer research, is needed.

Author (s) Details

Jagan Mohana Rao Saketi
Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, A.P., India.

S. N. Murthy Boddapati
Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, A.P., India.

M. Raghuram
Department of Botany & Microbiology, Acharya Nagarjuna University, Guntur-522510, A.P., India.

Syed Farooq Adil
Department of Chemistry, College of Science, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia.

Mohammed Rafi Shaik
Department of Chemistry, College of Science, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia.

Osamah Alduhaish
Department of Chemistry, College of Science, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia.

M. Rafiq H. Siddiqui
Department of Chemistry, College of Science, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia.

Hari Babu Bollikolla
Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, A.P., India.

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