Study on Primary Angiitis of Central Nervous System

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Study on Primary Angiitis of Central Nervous System

September 10, 2021 Medicine and Medical Research 0

The goal of this study is to look at the clinical aspects of primary central nervous system angiitis (PACNS) and examine the available literature.

Background: Primary angiitis is a rare condition that can be difficult to identify because there are so many symptoms that resemble it.

Case Specifics: On examination, a 45-year-old female patient had a headache, slurred speech, and bilateral pyramidal symptoms. On bilateral cranial imaging, there were lesions with little enhancement. She was put on antitubercular therapy and steroids based on the radiologist’s recommendation, and she made a significant recovery. There was a recurrence of symptoms in the form of slurred speech and seizures five months after the steroids were discontinued. The lesions recurred in the same regions after repeated brain imaging. An open brain biopsy revealed vasculitic disease with transmural vascular inflammation and fibrinoid necrosis in a few areas. The results of a thorough examination for systemic vasculitic diseases were negative. Corticosteroids were used to start immunosuppression, followed by cyclophosphamide. In the two-year follow-up, there was a significant improvement. The goal of this research is to look into the current literature on the diagnosis and therapy possibilities for this mysterious condition.

Author (S) Details

Radhakrishna Hari
Care Hospitals, Nampally, Hyderabad, Telangana, India.

Bimal Prasad Padhy
Care Hospitals, Nampally, Hyderabad, Telangana, India.


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