Study on Synthesis and Biological Activities of Novel 1,7-dihydropyrazolo[3,4-d] imidazo[1,2-f] pyrimidines
A straightforward method has been developed to synthesize new anti-inflammatory 1,7-dihydropyrazolo[3,4-d] imidazo[1,2-f] pyrimidine 5 from aminocyanopyrazole. These compounds were tested for anti-inflammatory, gastroprotective, analgesic, antioxidant, and anticandidal properties. After studying the structure-activity relationships, the compound 6-(4-methoxyphenyl)-3-methyl-1,7-dihydropyrazolo[3,4-d]imidazo[1,2-f]pyrimidine, 5a, was chosen as having the most potent activities. The structures of all novel compounds were determined using IR, 1H NMR, 13C NMR, and HRMS.
Author (s) Details
Laboratory of Medicinal and Environmental Chemistry, Superior Institute of Biotechnology of Sfax, University of Sfax, 3018, Sfax, Tunisia.
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