Study on the Altered Gonadal Expression Levels of the Adipokine Lipocalin-2 and the 24p3 Receptor in the Offspring of Obese Rats

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Study on the Altered Gonadal Expression Levels of the Adipokine Lipocalin-2 and the 24p3 Receptor in the Offspring of Obese Rats

September 8, 2021 Medicine and Medical 0

Currently, metabolic syndrome is a medical and economic issue that affects almost every country. Millions of people worldwide are affected by obesity, which is one of its components. Numerous studies have found a link between high levels of the adipokine lipocalin 2 (Lcn2) in the blood and various aspects of the metabolic syndrome. The latter is concerning since obesity is generally associated with chronic inflammation, resulting in dysregulation of adipokine production, which is often linked to the development of other cardiometabolic changes. It is also It’s well recognised that an obesogenic environment during pregnancy changes the expression of several molecules in the foetus, including adipokines. We recently discovered that Lcn2 and its receptor (24p3R) mRNA and protein expression is dysregulated in the gonads of obese rats’ offspring at various stages of development. We inferred from the findings that maternal obesity alters the expression of Lcn2 and 24p3R in the gonads of obese rats’ offspring, potentially through foetal programming. The effects of this dysregulation on the gonadal function of the children are yet to be determined.

Author(s) Details

Edgar Castrejón
Cardiovascular and Metabolic Diseases Research Unit, Mexico.

Leticia Manuel-Apolinar
Endocrine research Unit, National Medical Center, Mexican Social Security Institute, Mexico city 06720, Mexico.

Leticia Damasio
Endocrine research Unit, National Medical Center, Mexican Social Security Institute, Mexico city 06720, Mexico.

Rebeca López-Ballesteros
Cardiovascular and Metabolic Diseases Research Unit, Mexico.

MarÍa Cristina Revilla-Monsalve
Department of Biochemistry Diagnostics, Faculty of Higher Education, Cuautitlán Izcalli Campus, National Autonomous University of Mexico, State of Mexico 54714, Mexico.

Elsa de la Chesnaye
Department of Biochemistry Diagnostics, Faculty of Higher Education, Cuautitlán Izcalli Campus, National Autonomous University of Mexico, State of Mexico 54714, Mexico.

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