Studying Formulation and Physicochemical Characterization of Buccal Mucoadhesive Films Containing Alfuzosin Hydrochloride
The physiology of the mouth has allowed many drugs to be administered through the oral route. Another promising method for drug delivery is oral mucosal drug delivery, which has a range of advantages. The aim of this study was to embed a drug molecule, alfuzosin hydrochloride, in a sustained release buccal film for an 8-hour duration in order to prevent first-pass metabolism and increase bioavailability. Materials and Methods: In this research, sustained release formulations of alfuzosin hydrochloride buccoadhesive films were developed using the polymers HPMC, K100M, sodium alginate, and chitosan, and the prepared buccoadhesive films were systematically evaluated in vitro. To achieve a unidirectional release pattern, the films were given a backing layer of Eudragit RS100. Weight, thickness, material uniformity, folding durability, bioadhesive ability, surface pH, in vitro drug release, and ex vivo buccal permeation tests were all used to test the films. The solvent-cast films had a smooth and elegant look, were uniform in thickness, weight, and drug content, and had strong folding endurance. The formulations were found to be solid but not brittle based on mechanical properties. Different equations and kinetic models, such as zero order, first order, higuchi’s plot, and peppas plot, were used to suit the in vitro release results. The formulation A7 had the best mucoadhesive efficiency and matrix mediated release (2 percent HPMC K100 M and 2 percent chitosan). The value of the correlation coefficient (r) suggests that the drug release kinetics is zero order. A stability analysis of optimised films was performed, and both drug and buccal films were found to be stable. Conclusion: The new buccal formulation appears to be an ideal system for increasing drug bioavailability by preventing hepatic first-pass metabolism. Alfuzosin hydrochloride buccoadhesive films optimised with HPMC and chitosan can meet the ideal requirements for oral buccoadhesive films, and a therapeutically effective amount of alfuzosin hydrochloride can be provided through sustained release.
Author (s) Details
Abikesh Prasada Kumar Mahapatra
OPJS University, School of Pharmacy, Churu, Rajasthan-331303, India.
Sonia P. Nagvenkar
VerGo Pharma Research Laboratories Pvt. Ltd., Verna, Goa-403107, India.
Goa College of Pharmacy, Panaji, Goa-403107, India.
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