Lipase Mediated Synthesis of (3R)-Stiripentol
Racemic stiripentone was synthesised from piperonal and pinacolone and reduced to the alcohol stiripentol, which was obtained in high yield. Kinetic resolution of stiripentol catalysed by lipase A from Candida antarctica via esterification with vinyl butanoate has been performed with an E-value of 24. This allowed isolation of (3S)-stiripentol with an enantiomeric excess (ee) of…
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