QSAR Investigation on 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carbothioamides as EGFR Kinase Inhibitors

In order to establish a quantitative relationship between epidermal growth factor receptor (EGFR) kinase inhibitory activity and physicochemical / structural properties, a quantitative structure activity relationship (QSAR) study was performed on a series of 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carbothioamides. Using multiple linear regression (MLR) analysis, many statistical regression equations were developed. Model 2 justifies 72 percent (r2 = 0.7194)…
Read more

May 3, 2022 0