Detailed Study on Synthesis, Characterization and Solubility Determination of 6-phenyl-pyridazin-3(2H)-one in Different Pharmaceutical Solvents
The synthesis, characterization, determination of solubility and solution thermodynamic properties of the cardiovascular drug 6-phenylpyridazine-3(2H)-one (PPD) in 12 different pharmaceutical solvents is proposed for this analysis at temperatures ‘T = 298.2-318.2 K’ and pressure ‘p = 0.1 MPa.’ The calculated solubilities of PPD were regressed well with “van’t Hoff and Apelblat models”. Using differential scanning…
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