Tag: acetylcholinesterase

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Impairment in Acetylcholinesterase Activity in Different Brain Parts of Female Mice, Mus musculus Following 17 α-Methyltestosterone (Anabolic- Androgenic Steroid)

Anabolic androgenic steroids (AAS) are synthetic versions of testosterone, the male sex hormone. In this study, we looked at the effects of one of the AAS chemicals, 17-methyltestosterone, on acethylcholinesterase (AChE) enzyme activity in the forebrain, hippocampus, midbrain, and hindbrain of mice. Adult female mice were randomly assigned to one of four experimental groups, each…
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August 24, 2021 0

Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis and Their Anti-cholinesterase Activity

Vietnamese Huperzia squarrosa was isolated from a sequence of lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8pha-hydrophlemariurine B (5) and huperzinine (6). Among them, the latest natural source metabolite is lycosquarosine A (1). Dose-dependent AChE activity was completely inhibited by lycosquarosine A with an IC50 value of 54.3…
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February 13, 2021 0