Von Willebrand Factor in Thrombo-inflammation and Cardiovascular Pathology
VWF is a large multimeric plasma glycoprotein that connects thrombosis and inflammation. It transports coagulation factor VIII, a component of the intrinsic coagulation pathway, and mediates platelet adhesion and leukocyte recruitment to vascular damage sites. In sepsis, VWF may operate as a link between bacteria and the vessel wall. The presence of ultra-large multimers of…
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