Study on Cardiac Ischemia and Ischemia/Reperfusion Cause Wide Proteolysis of the Coronary Endothelial Luminal Membrane: An Approach to Possible Dysfunctions

Background: Ischemia and ischemia-reperfusion (I/R) are two common clinical insults that affect the molecular structure of the coronary vascular endothelial luminal membrane (VELM) and cause a variety of microvascular dysfunctions. The related metabolic alterations, on the other hand, are little understood. We hypothesised that metabolic changes cause ischemia and I/R-induced structural and functional VELM modifications.…
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September 1, 2021 0