Assessing the Impact of MGMT Promoter Methylation as a Prognostic Marker in Patients with Glioma- A Single-Center Observational Study

Background: Via promoter hypermethylation in gliomas, the MGMT gene is epigenetically silenced and this alteration has emerged as a important therapeutic response predictor. The current study was aimed at correlating O6-methylguanine-DNAmethyltransferase (MGMT promoter gene) methylation status with response to alkylating agent-based therapy in high-grade gliomas Methods: For MGMT promoter methylation by methylation-specific PCR, 20 cases…
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November 5, 2020 0