Tag: Curcumin

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Determination of Cisplatin Effect on Head and Neck Squamous Cell Carcinoma Modulated by Erk1/2 Protein Kinases

The aim of this study was to investigate the role of extracellular signal-regulated kinases (ERK1/2) and/or p53 activation in the apoptotic process induced by cisplatin-CisPT treatment on two head and neck squamous cell carcinoma cell lines (FaDu and PE/CA-PJ49) and how curcumin (CRM) used as an adjuvant supports it. According to data, CRM enhances CisPt…
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August 9, 2022 0

A Literature Review on Neuroprotective Activities of Curcumin in Parkinson’s Disease

Dopaminergic neurons of the substantia nigra pars compacta (SNpc) are impacted by Parkinson’s disease (PD), a multisystem condition that causes a decrease in dopamine (DA) at their striatal terminals. Levodopa or DA receptor agonists are used to treat Parkinson’s disease because they replace the role of diminished DA in the striatum. Extended use of these…
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July 30, 2022 0

Assessment of RP-HPLC Method Development and Validation for Simultaneous Estimation of Thymoquinone and Curcumin in Dosage Form

The goal of this research is to create and verify a simple, specific, accurate, and exact HPLC technique for concurrently measuring Curcumin (CUR) and Thymoquinone (THQ) in bulk and formulation, following ICH guidelines for analytical method development and validation. Study Design: Using a C-18 Inertsil column and optimising factors, develop an RP-HPLC technique for quantifying…
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May 3, 2022 0

Determination of Phytochemicals as Potential Inhibitors of Matrix Metalloproteinases (MMPs) with Special Reference to Breast Cancer

  Breast cancer is the most frequent cancer in women in India and around the world. Metastasis and secondary tumour growth are the leading causes of mortality and poor clinical prognosis in most malignancies, including breast tumours, and metastasized cancers remain essentially untreatable even with modern therapeutic options. MMPs, a family of zinc-dependent endopeptidase enzymes,…
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September 27, 2021 0

Everyday Phytochemicals for Cancer: Another Look

Phytonutrients, also known as phytochemicals, are plant-based ingredients that help to maintain, protect, and improve our overall health and well-being, including cancer prevention and other preventative activities in the body. Both fruits, vegetables, greens, and herbs contain them. Bioactive compounds/nutrients are abundant in marine species such as algae, seaweed, and sponges. They have antioxidant, anti-cancer,…
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April 14, 2021 0

Study on Silica Catalyst Promoted One-Pot Synthesis of 4-[(Dialkylamino)methyl]-1,7- diphenylhepta-1,6-diene-3,5-dione

Silica (SiO2) catalyses 4-[(dialkylamino)methyl]-1,7-diphenylhepta-1,6-diene-3,5-dione single-pot synthesis. The expeditious synthesis of Mannich base derivatives under the microwave irradiation process for curcumin is known for its biological activity. Curcumin is naturally occurring, isolated from Curcuma longa, yellow pigments, structurally polyphenolic compounds consisting of spectacular biological activity. Curcumin, which is grown in most parts of India, is also…
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December 30, 2020 0

Research on Aloe vera Mucilage as Solubility Enhancer in Tablet Formulation

The present study evaluates the synthesis of water-insoluble compounds into tablets with a sustained release matrix and the effect of aloe vera gel powder on the dissolution and other physical properties of tablets with the SR matrix. As a polymer, HPMC and ethyl cellulose were used and various  The concentration of aloe vera gel powder…
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September 28, 2020 0

Curcumin, Indomethacin, and Naproxen Synergistically inhibit the Growth of Human Colorectal Cancer Cells (HT-29): Current Research

The aim of this study was to investigate the effect of curcumin, indomethacin, curcumin and naproxen combination synergistically on the growth of HT-29 cells. The growth of HT-29 cells was examined by MTS cell viability assay by one to four days’ treatment with curcumin (10∼50 μM), indomethacin (250∼1,000 μM), curcumin (10∼50 μM) and naproxen (250∼1,000…
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July 6, 2020 0

Turmeric (Curcumin) as a Supplement in the Reduction of Inflammation in a Collagen-induced Arthritis Rat Model

Aims: To assess the therapeutic effect of turmeric (curcumin) supplementation in modulating the expression of NF-κB in the joints of collagen-induced arthritis (CIA) rats. Place and Duration of Study: Department of Postgraduate Studies and Research, International Medical University, Malaysia, between July 2011 and May 2012. Methodology: Arthritis was induced in each group of Dark Agouti…
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July 4, 2020 0