The aim of this study was to investigate the role of extracellular signal-regulated kinases (ERK1/2) and/or p53 activation in the apoptotic process induced by cisplatin-CisPT treatment on two head and neck squamous cell carcinoma cell lines (FaDu and PE/CA-PJ49) and how curcumin (CRM) used as an adjuvant supports it. According to data, CRM enhances CisPt…
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Dopaminergic neurons of the substantia nigra pars compacta (SNpc) are impacted by Parkinson’s disease (PD), a multisystem condition that causes a decrease in dopamine (DA) at their striatal terminals. Levodopa or DA receptor agonists are used to treat Parkinson’s disease because they replace the role of diminished DA in the striatum. Extended use of these…
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The goal of this research is to create and verify a simple, specific, accurate, and exact HPLC technique for concurrently measuring Curcumin (CUR) and Thymoquinone (THQ) in bulk and formulation, following ICH guidelines for analytical method development and validation. Study Design: Using a C-18 Inertsil column and optimising factors, develop an RP-HPLC technique for quantifying…
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Phytonutrients, also known as phytochemicals, are plant-based ingredients that help to maintain, protect, and improve our overall health and well-being, including cancer prevention and other preventative activities in the body. Both fruits, vegetables, greens, and herbs contain them. Bioactive compounds/nutrients are abundant in marine species such as algae, seaweed, and sponges. They have antioxidant, anti-cancer,…
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Silica (SiO2) catalyses 4-[(dialkylamino)methyl]-1,7-diphenylhepta-1,6-diene-3,5-dione single-pot synthesis. The expeditious synthesis of Mannich base derivatives under the microwave irradiation process for curcumin is known for its biological activity. Curcumin is naturally occurring, isolated from Curcuma longa, yellow pigments, structurally polyphenolic compounds consisting of spectacular biological activity. Curcumin, which is grown in most parts of India, is also…
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The present study evaluates the synthesis of water-insoluble compounds into tablets with a sustained release matrix and the effect of aloe vera gel powder on the dissolution and other physical properties of tablets with the SR matrix. As a polymer, HPMC and ethyl cellulose were used and various The concentration of aloe vera gel powder…
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The aim of this study was to investigate the effect of curcumin, indomethacin, curcumin and naproxen combination synergistically on the growth of HT-29 cells. The growth of HT-29 cells was examined by MTS cell viability assay by one to four days’ treatment with curcumin (10∼50 μM), indomethacin (250∼1,000 μM), curcumin (10∼50 μM) and naproxen (250∼1,000…
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Aims: To assess the therapeutic effect of turmeric (curcumin) supplementation in modulating the expression of NF-κB in the joints of collagen-induced arthritis (CIA) rats. Place and Duration of Study: Department of Postgraduate Studies and Research, International Medical University, Malaysia, between July 2011 and May 2012. Methodology: Arthritis was induced in each group of Dark Agouti…
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