Negative Regulation of Wnt/β-catenin Signaling is Blocked by Wnt Signaling Component Protein Dishevelled1 Binding Aptamer (WD-Aptamer): A Recent Study

Dishevelled1 (Dvl1) is made up of three domains that have a function in Wnt/-catenin signalling. The DIX domain is responsible for Dvl1 polymerization, whereas the DEP domain is responsible for Dvl1 binding to other signal transduction molecules and the PDZ domain is responsible for binding to the membrane-bound receptor Frizzled. CXXC5 is one of several…
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August 17, 2021 0