A Review on the Pathology and Diagnosis of Mantle Cell Lymphoma

A uncommon type of B-cell non-Hodgkin lymphoma (NHL), Mantle Cell Lymphoma (MCL) is characterised by an aggressive clinical path and a poor prognosis that remains incurable for the majority of patients. The pathogenic hallmark of MCL disease is cyclin D1 overexpression, which results from t(11; 14)(q13; q32), and causes cell cycle disruption. In the WHO…
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December 14, 2020 0