Tag: cycloaddition

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Study on Regioselective Three Component Domino Synthesis of Polyhydrospiro [indoline-3,3’-pyrrolizine]-2-one via [3+2] Cycloaddition Reaction under Ultrasonic-Irradiation

Due to its interesting structure and biological significance, Spiro compounds with attached indole moiety having an all-carbon quaternary stereogenic core have attracted synthetic organic chemists. In present work we have reported synthesis and characterisation of novel Hexahydrospiro [indoline-3,3′-pyrrolizine]-2-one derivatives in good to excellent yields through [3+2] cycloaddtion reaction in regioselective manner under ultrasonic irradiation. Via…
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December 31, 2020 0

Synthesis of Some New Spiro β-lactams and Thiazolidinones Compounds Containing Sulfur Incorporating Quinon Compounds: Advanced Study

Compounds 4 have been synthesized by cycloaddition reaction of, chloroacetyl chloride and mercaptoacetic acid with the synthesized Shiff,s bases 5a-c to afford new spiroβ-Lactam 6a-c and spirothiazolidinone7a-c the cycloaddition were characterized by spectral data including HNMR,13 CNMR, IR and elemental analysis. Author(s) Details N. A. A. ElKanzi Department of Chemistry, College of Science, Jouf University,…
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July 29, 2020 0

Mono, Bi and Trihetercyclic Compounds: Synthesis, Characterization, Physicochemical, Structural and Biological Properties

The synthesis of new mono-, bi- and tri-heterocyclic carboxylic and phosphonic acid models are attracting the interest of research teams around the world due to the broad spectrum of activity they present. Indeed, these biomolecules constitute a class of compounds active in biochemistry, enzymology, medicine, agrochemical industry, and pharmacology. The Professors and Researchers, members of…
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April 8, 2020 0

Synthesis and Characterization of N-((tetrazol-5 yl)methyl)cyclohexanamine through 2D NMR Experiments: An Overview

Tetrazoles are an important class of nitrogen containing heterocycles with a wide range of medicinal and commercial applications. Tetrazolyl analogs of amino acids exhibit versatile biologic activity, and some of them are known pharmaceuticals. In addition, compounds of this type may be using in development of radiopharmaceuticals for positron emission tomography. In continuation of our…
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March 16, 2020 0