Tag: cyclophosphamide

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Assessment of Chronic Inflammatory Demyelinating Polyneuropathy in Systemic Lupus Erythematosus

The central nervous system (CNS) is more commonly affected than the peripheral nervous system in Systemic Lupus Erythematosus (SLE). Neuropsychiatric or CNS signs are widespread, ranging from 24-54 percent, while peripheral nervous system involvement is less common, at roughly 5-27 percent. Chronic Inflammatory Demyelinating Polyradiculopathy (CIDP) is one of the three most common peripheral nerve…
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May 7, 2022 0

Reduction of Oral Mucositis Severity using a Topical Vasoconstrictor in Bone Marrow Transplant Patients

Oral mucositis (OM) of grade 3 has been seen in over 90% of bone marrow transplant patients who received the cyclophosphamide + whole body irradiation (CY+TBI) conditioning regimen in the past. In two preclinical animal models, an orotopically administered adrenergic vasoconstrictor prevented up to 100 percent of radiation-induced oral mucositis. Three patients (ages 24-29) who…
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September 15, 2021 0

Recent Study on Immunosuppressive Treatment for Lupus Nephritis: Long-term Results in 178 Patients

Lupus nephritis is one of the most severe Systemic Lupus Erythematosus features, defining treatment modality and prognosis. Our retrospective study, including 178 patients treated for lupus nephritis during 23 years with mostly cyclophosphamide-based initial regimens followed by azathioprine or mycophenolic acid, demonstrates 84.8% of renal response with 19.2% of flares, 15-year patient survival 78.7% and…
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July 2, 2020 0