The Role of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Recognition of Pseudomonas aeruginosa in Lung Epithelial Cells: Detailed Study

Cystic Fibrosis Transmembrane Regulator (CFTR) plays an important role in chloride and thiocyanate ion homeostasis in human epithelial surfaces. Deletion of phenylalanine at position 508 (Δ508) leads to cystic fibrosis and dysregulation of pro-inflammatory cytokines. Pseudomonas aeruginosa gains predominance, contributing over 80% of the lung bacteria in adults with CF and this strongly correlates with…
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April 6, 2020 0