A Most Recent Approach for the Stereoselective Synthesis of (+)­epi­Cytoxazone

Discovery of the biological potentialities of cytoxazone by Kakeya’s research group has leveraged the development of studies aimed at the synthesis of this compound. The stereoselective total synthesis of (+)-epi-cytoxazone was performed satisfactorily in 8 steps, in 17% overall yield, via a novel route from 2,3-O-(3-pentylidene)-(R)-glyceraldehyde. The bulky group alkene-ketal allowed intramolecular control of the…
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September 17, 2020 0