Tag: inflammation

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Defining Parallels between the Salivary Glands and Pancreas to Better Understand Pancreatic Carcinogenesis: A Comparative Review

A highly malignant tumor with a dismal prognosis is pancreatic ductal adenocarcinoma (PDAC), primarily due to its late presentation. In 2015, in the Western world, PDAC was ranked fourth in terms of tumor-related mortality. In the asymptomatic phase of the disease, this is at least in part due to its rapid spread. Early detection methods,…
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February 8, 2021 0

Assorted Advances Therapeutic Strategies of Inflammatory Arthritis

A type of inflammatory disease, arthritis is a complex group of conditions characterised by inflammation of the joints that can typically affect one or more joints, deformity, and disability. Various environmental and other causative factors affect approximately 100 different types of arthritis, but the two most common types are osteoarthritis and rheumatoid arthritis. Osteoarthritis can…
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January 6, 2021 0

Rheumatoid Arthritis

Rheumatoid arthritis(RA) is a chronic polyarticular inflammatory disease which leads to swelling of the joints, deformity and loss of joint function. RA occurs in 1 to 3 percent of the adult population, with significantly more women than men affected. The body’s immune system attacks its own tissue, including joints, during rheumatoid arthritis. It attacks internal…
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January 6, 2021 0

An Overview of Periodontal Disease and Diabetes Mellitus

The most prevalent chronic diseases in the world’s adult population are diabetes mellitus and chronic periodontitis. Diabetes mellitus is a clinically and genetically heterogeneous group of metabolic disorders in which blood glucose levels are abnormally large. Periodontitis[1], on the other hand, is an inflammatory teeth-supporting tissue disease caused by a particular microorganism or community of…
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October 17, 2020 0

Biochemical and Molecular Pathogenetic Mechanisms behind Causation of Parkinson’s Disease

Parkinson’s disease (PD) is an age-related neurodegenerative disorder that affects approximately 1 million persons in the United States. It is characterized by resting tremor, rigidity, bradykinesia, gait disturbance and postural instability. Its pathological features include degeneration of dopaminergic neurons in the substantia nigra pars compacta coupled with intracytoplasmic inclusions known as Lewy bodies. Neurodegeneration and…
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July 27, 2020 0

Immuno-inflammatory Aspects of Interleukin-21 in Periodontal Sequelae: Current Development

Interleukin-21 (IL-21) has a dual anti-inflammatory and pro-inflammatory role in chronic inflammation. It causes breakdown of other surrounding hard and soft tissues by coupling with other destructive mediators, along with increasing several other proinflammatory cytokines. This chapter describes concepts in relation to effects of IL-21 on critical immune cells of both innate and adaptive immune…
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July 2, 2020 0

Study of In vitro Anti-inflammatory Property of Dendrocnide sinuata (Blume) Chew and Chenopodium ambrosioides (L.): Ethnomedicinal Plants from Assam

Traditionally many of the medicinal plants are used by Assamese people to treat various ailments, of them Dendrocnide sinuata and Chenopodium ambrosioides are used for treating inflammation- related diseases. The present study was carried out to investigate and verify the anti-inflammatory property of Dendrocnide sinuata and Chenopodium ambrosioides by in-vitro human red blood cell (HRBC)…
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July 1, 2020 0

The Effect of Ethanol Extract of Xylopia aethiopica Fruits on the Histomorphology of the Kidney of Albino Wistar Rats: Advanced Study

Aims: The study investigated the effect of ethanol extract of Xylopia aethiopica fruits on the histomorphology of the kidney of albino Wistar rats. Study Design:  Twenty (20) albino Wistar rats weighing between 130–180 g were assigned into four (4) groups of five rats each. Group 1 served as the control group. Groups 2, 3 and…
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April 4, 2020 0

Phospholipase A2 Inhibition and Antiinflammatory Activity of F4 Fraction of Total Ethereal Leaf Extract of Annona senegalensis Pers. (Annonaceae)

Annona senegalensis Pers. (Annonaceae) is a plant which is used in african traditional medicine for the treatment of various diseases. This study aimed to investigate the analgesic and anti-inflammatory activity of total ethereal leaf extract fractions of A. senegalensis. Compounds of methanolic fractions of ethereal leaf extract of A. senegalensis were separated by gel sephadex…
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December 16, 2019 0

TNF-α Inhibitor Treatment for Crohn’s Disease: Comparative Review of Post Therapy Malignancy between Infliximab and Adalimumab

The association between chronic inflammatory disease and cancer has been well established through years of research. In corollary, progressive resistance to chimeric monoclonal antibodies has been reported in literature. The purpose of this investigation was to establish the overall trend of the chimeric monoclonal antibody (Infliximab) failure compared with human monoclonal antibody (Adalimumab). It was…
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October 28, 2019 0