Tag: metabolism

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A Systematic Review on Metabolite Profiling in Anticancer Drug Development

 Drug metabolism is one of the most significant pharmacokinetic processes and is essential to the creation of new medications. Because the metabolites generated may be beneficial for therapy or seriously harmful, it is crucial to examine the metabolite profile. The purpose of this systematic review is to provide an overview of the literature on the…
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August 5, 2022 0

Evaluating the Effects of 24-Week Intervention with High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Individuals with Metabolic Syndrome

The researchers want to see how HRW affects blood lipids, inflammation, oxidative stress, and glucose levels, as well as phenotypic alterations like body mass and waist-to-hip ratio. Molecular hydrogen (H2) has been shown to alleviate chronic inflammation, minimise oxidative stress, and enhance cellular function. Although preclinical and clinical research have demonstrated that H2-rich water (HRW)…
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May 25, 2022 0

Recent Trends in Ethylene Glycol Monomethyl Ether Research

Ethylene glycol monomethyl ether (EGME) is a solvent that has a wide range of applications. The results of studies on EGME in humans and animals undertaken over the previous two decades are presented in this chapter. The documentation supports EGME’s classification as a gonadotoxicant, with implications for haematological, oxidative state, apoptosis, inflammation, gene expression, and…
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January 11, 2022 0

Determination of the Anti-diabetic Activity of Sphenostylis stenocarpa Seed Milk Extract in Alloxan-induced Diabetes Rats

Diabetes mellitus is a chronic metabolic disorder characterised by improper glucose, protein, and lipid metabolism. It’s generally connected with glycosuria, or the discharge of too much sweet urine. The majority of anti-diabetes medicines are not only expensive, but they also come with a significant level of drug toxicity. The anti-diabetic effect of seed milk extract…
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January 8, 2022 0

Rethinking Autoimmunity in Regenerative Medicine: A Review of Diabetic Treatment Options

T1DM is an autoimmune disease in which auto-reactive cytotoxic CD8+ T-cells destroy native pancreatic insulin-producing islet of Langerhans cells, resulting in a reduction in endogenous insulin levels. The goal of this chapter is to present a synopsis of recent breakthroughs that provide new perspectives on the future of autoimmunity as it relates to regenerative medicine…
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December 4, 2021 0

A Short Review on Polyamine Metabolism in Sperm Cell

Putrescine, spermidine, and spermine are polyamines that occur naturally in living organisms. They can be found in tissues and fluids of mammals. They communicate with a number of polyanions, including nucleic acids, since they are simple molecules. Polyamines help to keep deoxyribonucleic acid stable. Their function in diabetes mellitus and reproductive disorders, not only in…
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April 28, 2021 0