Tag: Plasmodium falciparum

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Rapid Diagnostic Tests for Malaria: Challenges and Future Prospects, a Brief Review

Malaria is a major socioeconomic burden on humanity and a leading cause of infectious diseases worldwide. This parasitic disease affects nearly 90-95% of countries and territories in tropical and subtropical regions. About 40% of the world’s population is affected by and suffers from malaria. Malaria is one of the most important vector-borne diseases in India.…
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October 28, 2022 0

Antimalarial Activity of the Extracts of Vernonia Amygdalina Commonly Used in Traditional Medicine in Nigeria: An in vitro Study

In the tropics and subtropics, malaria is a serious infectious illness. Antimalarial drug resistance in P. falciparum has required the quest for new antimalarial agents. Vernonia amygdalina, a plant used by traditional healers to cure malaria and other ailments, was tested in vitro against 14 fresh isolates of Plasmodium falciparum from Damboa, Borno State, Nigeria.…
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August 21, 2021 0

An Evaluation and Assessment of the Effects of Insecticide-Treated Livestock Protective Fences (LPF) for Protecting Humans from Anthropophilic Mosquitoes and Malaria Transmission in a Suburb of Kumasi in the Forest Zone of Ghana

The chapter investigates whether a 100 cm high livestock protective fence (LPF) protects humans from anthropophilic mosquitoes (mosquitoes that are attracted to and bite humans) and thus malaria. Four experimental segregated, half-roofed shelters with concrete floors were built to accomplish this. Each shelter was 6m x 7m in size and 500m apart from the other.…
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July 8, 2021 0

Reduced Effective T Helper Responses against Plasmodium falciparum and Schistosoma mansoni Co-Infection in ex vivo: Th1, Th2 & Th17 Immune Responses

Background: Parasitic worms evade immune responses, and interactions between diseases can result in different immunologic outcomes than single infections. These interactions could have an impact on vaccine and chemotherapeutic efficacy. Schistosoma mansoni and Plasmodium falciparum are co-endemic in Uganda and are the most common parasitic causes of public health problems throughout Sub-Saharan Africa. Plasmodium falciparum…
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July 7, 2021 0

An Overview of Plant-Derived Drugs in Malaria Treatment

Artesunate and quinine, both obtained from plants, are also used to treat acute malaria. The use of successful antimalarial drug formulations against the highly mutable parasite Plasmodium falciparum is reviewed in this brief summary. Author (s) Details E. Hempelmann Department of Science in Biochemistry, University Tuebingen, Germany. View Book :- https://stm.bookpi.org/TIPR-V2/issue/view/55


March 11, 2021 0

Advanced Study on Assay of Quinine Utilizing Isocratic HPLC Solvent Conditions and Feasibility of Assay from Human Urine

Using isocratic solvent conditions and high-performance liquid chromatography, the assay of quinine sulfate, a medication provided for the clinical treatment of Plasmodium falciparum, can be performed (HPLC). The most serious form of human malaria is caused by Plasmodium falciparum (P. falciparum), which has been found to be responsible for 85 percent of all cases of…
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February 13, 2021 0

In silico Evaluation of Antimalarial from Bioactive Compounds of Bitter Melon (Momordica charantia L.) and Its Toxicity with Plasmodium falciparum Lactate Dehydrogenase (PfLDH) and Plasmepsin (Plm) Enzymes as Targets

Malaria is one of the important health problems in the world caused by intracellular obligate protozoa of the genus plasmodium. P. falciparum causes the most severe infections and the highest mortality rate. The previous in vivo and in vitro research of crude alkaloid on bitter melon fruit (Momordica charantia L.) can prove antimalarial activity in…
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June 8, 2020 0

Prevalence and Intensity of Plasmodium falciparum Malaria and the Challenges of Microscopy and Rapid Test Diagnosis (RDT) Diagnostic methods in North- Western Nigeria

Aims: The study was undertaken to estimate the prevalence and intensity of Plasmodium falciparum infection, in randomly selected areas of north-western Nigeria and to evaluate the efficiency of microscopy and rapid diagnostic test (RDT) in detecting and determining intensity of P. falciparum infection. Study Design: The study was conducted in north –western Nigeria, between April…
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August 26, 2019 0

Contribution in the Malaria Control of Substituted 5- chloro-3,4-dihydro-1H-pyrano[3,4-b]-1,10- phenanthrolinone Compounds: Antiplasmodial and Cytotoxic Activities

Background: Malaria is one of the most common parasitic disease in tropical and subtropical regions. Plasmodium falciparum, one of the causative agent of malaria is resistant to many type of antimalarial drugs. This study present in vitro assessment of the antiplasmodial activity of substituted phénanthrolinone compounds. Methods: A series of 7 substituents were used to…
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August 26, 2019 0