Recent Study on Therapeutic Targets in Gastrointestinal Stromal Tumors

The most common type of gastrointestinal mesenchymal tumour is gastrointestinal stromal tumours (GISTs). Carcinogenesis of GISTs is caused by gain-of-function mutations in KIT or plateletderived growth factor receptor (PDGFRA), which result in constitutive activation of the tyrosine kinase and its downstream signalling cascades. Imatinib, a KIT/PDGFRA inhibitor, is the standard of care for patients with…
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July 28, 2021 0