Design, Synthesis and Biological Evaluation of Substituted StyrylIncorporated Quinazoline Derivatives as Anticancer Agents

A novel sequence of substituted aryl ethynyl integrated quinazolines (11a-j) were designed and synthesised and 1HNMR, 13CNMR, and mass spectral analysis characterised their structures. In addition, these compounds were tested against human cancer cell lines such as MCF-7 (human breast cancer), A549 (human lung cancer), DU-145 (human prostate cancer) and MDA MB-231 (human breast cancer)…
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November 11, 2020 0