Study on Radiosensitization of Human Leukemic Cells by ATR Kinase Inhibitor (VE-821): Phosphoproteomic Analysis

The DNA damage response (DDR) is a critical mechanism for maintaining genomic stability since it promotes cell-cycle arrest and encourages DNA damage repair, resulting in resistance to a variety of genotoxic insults when activated. Ataxia telangiectasia mutated (ATM), DNA-dependent protein kinase (DNA-PK), and ATM and Rad3-related kinase are the three phosphatidylinositol 3-kinase-related kinases (PIKKs) that…
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March 11, 2021 0