Design and Evaluation of Gastroretentive Ranitidine HCL Sustained Release Bilayer Tablet Using Wax Matrix: A Recent Study

Background: This paper describes a study of floating bilayer tablets of Ranitidine HCl, an H2 receptor antagonist used to treat peptic ulcers. Ranitidine HCl has a 50 percent absolute bioavailability and is consumed only in the first portion of the small intestine. The gas-releasing portion, which is required for the tablet to float, is added…
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April 14, 2021 0