An Overview of Bacterial Superantigen Toxins, CD28, and Drug Development
Acute toxic shock is induced by superantigen toxins, a diverse set of proteins secreted by Grampositive staphylococcal and streptococcal bacterial strains that overstimulate the inflammatory response by orders of magnitude. The need to protect from superantigen toxins led to our discovery that in addition to the well-known MHC class II and T cell receptors, the…
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