The Appropriate Acyclic Precursors to Build Biologically Active 5-acylamino-1,3-thiazoles

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The Appropriate Acyclic Precursors to Build Biologically Active 5-acylamino-1,3-thiazoles

July 1, 2021 Chemistry and Biochemistry 0

The goal of this opinion piece is to highlight recent developments in the development of efficient catalyst-free synthesis of Hantzsch polysubstituted 1,3-thiazoles. They are heterocycles that are particularly important in the pharmaceutical industry, and the strategy involves the cyclization reaction of acyclic precursors with the least amount of auxiliary substances, toxic reagents, organic solvents, and disposal issues.

Author (S) Details

Mara Tomassetti
Dompé Farmaceutici S.p.A., Via Pietro Castellino, Napoli 80131, Italy

Gabriele Lupidi
School of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.

Serena Gabrielli
School of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.

Federico Vittorio Rossi
School of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.

Dr. Samuele Lillini
Dompé Farmaceutici S.p.A., Via Pietro Castellino, Napoli 80131, Italy.

Gianluca Bianchini
Dompé Farmaceutici S.p.A., Via Campo di Pile, L’Aquila 67100, Italy.

Andrea Aramini
Dompé Farmaceutici S.p.A., Via Pietro Castellino, Napoli 80131, Italy and Dompé Farmaceutici S.p.A., Via Campo di Pile, L’Aquila 67100, Italy.

Daniele Canestrari
Dompé Farmaceutici S.p.A., Via Campo di Pile, L’Aquila 67100, Italy.

Enrico Marcantoni
School of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.

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