The Clinical Significance of Inflammatory Biomarkers of Atherosclerosis in Carotid Disease
Ischemic stroke is commonly caused by atherosclerotic disease of the carotid arteries. The degree of carotid stenosis is the most important factor in determining the risk of stroke in “carotid disease,” although it cannot correctly predict future stroke. Carotid artery stenosis with no symptoms is a well-known risk factor for ischemic stroke. In the context of ulceration and plaque rupture, non-stenotic atherosclerotic carotid artery plaques can produce atheroembolism. The goal of this study was to synthesise the current information on the link between carotid atherosclerosis and serum inflammatory biomarkers. Atherosclerosis is a dynamic process characterised by inflammatory and thrombotic processes, as well as increasing stenosis. The capacity to forecast the course of atherosclerotic stenosis can be helpful in predicting the risk of stroke and preventing it in clinical practise. The goal is to identify a subgroup of patients who have a higher risk of ipsilateral stroke. Inflammatory activity is a critical factor in the pathogenesis, progression, and rupture of atherosclerotic plaque, as well as the development of clinical symptoms in individuals with atherosclerotic carotid stenosis. C-reactive protein, interleukin-6, pentraxin 3, lipoprotein-associated phospholipase A2, adhesion molecules ICAM-1, selectins, and matrix metalloproteinases have all been recommended as tools for risk assessment in patients with carotid atherosclerosis. Even though several cardiovascular biomarkers have been found, their prognostic usefulness is limited. Some well-known indicators for coronary artery disease aren’t applicable to carotid artery disease. The clinical importance of a serum inflammatory biomarker in carotid atherosclerosis may be clarified in the future.
Author (S) Details
Department of Neurology and Neurosurgery, Kharkiv Medical Academy of Postgraduate Education, Ukraine.
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