Topical Gel Loaded with Fluconazole Niosomes: Formulation and Evaluation Study

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Topical Gel Loaded with Fluconazole Niosomes: Formulation and Evaluation Study

August 6, 2022 Pharmaceutical Pharmaceutical 0

 Designing and evaluating topical gel-loaded fluconazole niosomes is the aim of the project. Fluconazole, a macrolide antibiotic, is used to treat a number of delicate bacteria. Niosomes can boost a drug’s skin penetration and lengthen its duration in the stratum corneum and epidermis while decreasing its absorption throughout the body. Because they may change pharmacokinetics and bioavailability as well as reduce toxicity, niosomes play a significant role in the administration of medications.

It was determined during the study that the sample is a pure substance. Fluconazole (pure medication) acquired Fourier transform infrared (FTIR 8400s, Shimadzu Japan) spectra were examined. The procedure of potassium bromide discs was utilised.

improved formulations With vesicle diameters of 845.6 nm and 164.2 nm, respectively, and zeta potentials of -10.2 mV and -46.4 mV, the formulation for FNS5 and FNT4 produced with Span-60 and Tween-60 is stable. The improved niosomes were then thoroughly assessed for zeta potential and vesicle size after being added to gels made of carbopol 934 and guar gum.

According to the study, drug retention, penetration, and release times were all prolonged when drugs were trapped in niosomes.

 

Author(s) Details:

Gajjala Sravan,
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, 500028, India.

K. Latha,
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, 500028, India.

R. Padmavathi,
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, 500028, India.

Maimuna Fatima,
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, 500028, India.

C. V. Sai Sravani,
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, 500028, India.

M. Saritha,
Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam, Andhra Pradesh-530049, India.

Please see the link here: https://stm.bookpi.org/CAPR-V5/article/view/7774  

Keywords: Niosomes, fluconazole, carbopol 934, guar gum

 

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