Valsartan – A Critical Review of Analytical Methods
Valsartan is a new potent antihypertensive drug, highly selective and orally active, belonging to the Type I receptor antagonist family of Angiotensin II. It is a lipophilic drug and was first developed in the developed and developing countries by Novartis and has a wide market. It is used as a single prescription and in combination with other medications for antihypertension. After oral administration, Valsartan is easily absorbed. Recent advances in analytical techniques for estimating Valsartan alone or in combination with other drugs in different biological media, such as human plasma and urine, are the subject of this study. The analytical methods of UV spectroscopy, high performance liquid chromatography (HPLC), ultra performance liquid chromatography (UPLC), high performance thin layer chromatography (HPTLC), liquid chromatography coupled with tandem mass spectrometry will be critically analysed in this study (LC-MS). The analysis will allow analytical chemists to know the main solvents and their combinations in the analytical laboratory for their available collection of instruments. The successful combination of parameters can reduce the cost of the analysis, and the analytical method is responsible for reducing the time needed for output. The methods are also useful for evaluating parameters during API manufacturing for in-process evaluation.
Author (s) Details
Department of Pharmaceutical Analysis, Vinayaka Missions College of Pharmacy, Salem-636008, Tamilnadu, India.
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