Vitamin D deficiency and Its Link with Inflammatory Markers in Women
Aim: Vitamin D deficiency is a serious health problem that affects people of all ages, particularly elderly women. Menopause is a significant event in a woman’s life. Women are becoming more susceptible to a variety of metabolic diseases as they get older. The purpose of this study is to determine serum vitamin D and hs-CRP levels in premenopausal and postmenopausal women.
Methods: The study included 500 female participants, with 400 pre- and postmenopausal women serving as cases and 100 serving as healthy controls. Vitamin D levels in serum were measured using a chemiluminescent microparticle immunoassay, and hs-CRP levels were measured using a latex-enhanced turbidimetric immunoassay. All female subjects were tested for serum estradiol (E2) using a competitive immunoassay method. SPSS software, version 22.0, was used to analyze the data. When pre- and postmenopausal women were compared to healthy control women, vitamin D levels were significantly lower and hs-CRP levels were significantly higher (p0.001). Serum estradiol levels were also significantly lower in postmenopausal women. We discovered a strong negative correlation between vitamin D deficiency and hs-CRP levels in both pre- and postmenopausal women.
Conclusion: Postmenopausal women are more likely than premenopausal women to be vitamin D deficient. Low-grade systemic inflammation has been linked to an increased risk of cardiovascular disease, diabetes, and metabolic syndrome in postmenopausal women.
Author (s) Details
Dr. Deepa Gupta
Department of Biochemistry, NAMO Medical Education & Research Institute, Silvassa, India.
University of Kota, Rajasthan, India.
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