Wound Healing Potential of GTN in Wistar Rats
The goal of this study was to see how effective Glyceryl trinitrate is at healing wounds in wistar rats.
Materials and Methods: We took 18 male wistar rats and separated them into three groups, each with six rats. Glyceryl trinitrate, Ointment base, Control (Normal saline). The nape of their necks were shaved, they were fasted overnight, and surgery was performed the next day under general anaesthesia. With a scalpel blade, a 500 mm2 circular excisional wound was formed. Since the next day of wounding, Glyceryl trinitrate, control, and ointment base have been applied topically. On the 6th, 10th, y, and 14th days, the wound was traced with polythene paper and the area was measured with a planimeter.
The wound contraction and the duration of epithelization were the two characteristics evaluated. In comparison to control, glyceryl trinitrate showed a statistically significant difference in wound contraction. Glyceryl trinitrate considerably shortened the time it took for epithelization compared to the Control and Ointment base treatment groups.
Author (S) Details
S. A. Surale-Patil
Department of Pharmacology Krishna Institute of Medical Sciences Deemed To be University, Karad, Maharashtra, India.
T. R. Patil
Gurukripa, Station Road, Miraj, Maharashtra, India.
R. P. Kulkarni
Bharati Vidyapeeth Deemed University Medical College & Hospital, Sangli, India.
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